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Updated: Sep 11, 2025

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用于控制自闭症谱系障碍儿童的攻击性和易怒性的Divalproex:系统性审查

Daisy Valle¹, Ethan Jetter¹, Jamie Warner¹

¹University of Florida College of Medicine, Gainesville, FL, USA.

Journal of child and adolescent psychopharmacology

|August 11, 2025

概括

通过静脉注射,Divalproex对患有自闭症谱系障碍 (ASD) 的儿童的急性攻击性有前途. 口服使用在慢性症状方面产生了不一致的结果,并指出了副作用.

科学领域:

神经科学是一个神经科学.
儿科精神病学儿科精神病学
药理学药理学是指药理学的学科.

背景情况:

攻击性和易怒性是自闭症谱系障碍 (ASD) 儿童面临的重大挑战.
药理干预通常是必要的,尽管有效性不清楚,但divalproex被非标签使用.
本综述评估了divalproex在儿童ASD中治疗这些症状的有效性和安全性.

研究的目的:

系统地审查divalproex在治疗ASD儿童的攻击性和易怒性方面的疗效.
为了评估这群人群中与divalproex治疗相关的安全性概况和不良影响.

主要方法:

进行了PRISMA引导的系统审查,搜索主要的生物医学数据库.
研究包括使用divalproex,酸或酸治疗ASD的儿童.
数据提取侧重于研究设计,干预措施,结果和不良事件.

主要成果:

十项研究 (3项RCT,1项开放标签,6项病例报告) 符合纳入标准.
静脉注射divalproex迅速降低了侵略性,这表明急性稳定性的潜力.
口服divalproex对慢性症状的疗效不一致;不良反应包括体重增加,镇静和行为激活.

结论:

静脉注射divalproex可能有利于小儿ASD急性侵略管理.
口服divalproex在慢性症状管理中的作用是不确定的,因为结果和副作用不一致.
建议定期监测血清并考虑慢性使用的替代品.

关键词:

攻击性侵略性攻击性自闭症谱系障碍 (ASD)这是一个二进制的proexex.易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒儿科心理药理学儿科心理药理学瓦尔酸是一种酸.

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