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通过建立全球AOP网络,推进基因毒性评估

E Demuynck^1,2, T Vanhaecke², A Thienpont¹

¹Scientific Direction of Chemical and Physical Health Risks, Sciensano, Brussels, Belgium.

Environmental and molecular mutagenesis

|August 11, 2025

概括

基因毒性测试的现代化需要综合测试和评估方法 (IATA). 这些框架使用新方法方法 (NAM) 来提高准确性并减少动物使用.

科学领域:

毒理学毒理学毒理学
遗传学是一个遗传学.
监管科学监管科学

背景情况:

目前的基因毒性测试面临着诸如误导性结果和有限的机制性见解等挑战.
现有的测试电池缺乏集成先进技术和定量评估.
需要在基因毒性评估中减少对动物试验的依赖.

研究的目的:

探索对基因毒性评估的欧洲监管框架中的挑战.
讨论对基因毒性进行测试和评估的综合方法 (IATA) 的开发和实施.
为DNA损伤提供全球不良结果途径 (AOP) 网络,以指导IATA的发展.

主要方法:

审查当前的基因毒性测试策略和监管框架.
探索新方法方法 (NAM),如3D系统,毒素追踪器和转录生物标志物.
应用不利结果路径 (AOP) 框架,将NAM集成到IATA中.

主要成果:

确定了当前基因毒性评估中的关键挑战和缺口,特别是在欧洲法规中.
强调了NAM和AOP的潜力,以创建更准确和更有效的基因毒性测试.
建议建立一个针对永久性DNA损伤的全球AOP网络,以支持监管决策.

结论:

在AOP的指导下,IATA集成NAM对于现代化基因毒性评估至关重要.
这种方法可以提高准确性,效率和道德标准,同时减少动物试验.
拟议的AOP网络为改善化学安全评估的监管决策提供了一个框架.

关键词:

在 AOP AOP 中.国际航空交通协会 (IATA) 的这些是NAMs.遗传毒性遗传毒性遗传毒性遗传毒性

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