慢性鼻炎患者的肠道微生物群体对1,8-Cineol治疗的反应
Simon Graspeuntner1,2, Mathias Heidemann3, Stephanie Jeschke3
1Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.
Current research in microbial sciences
|August 11, 2025
概括
用于慢性鼻炎 (CRS) 的植物性抗炎药物1,8-Cineol不会显著改变肠道微生物群. 这表明1,8-Cineol是标准CRS治疗的安全补充,特别是在儿童中.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 慢性鼻炎 (CRS) 是一种常见的炎症状况,需要像抗生素这样的治疗,这可能会对肠道微生物多样性产生负面影响并增加耐药性.
- 需要替代疗法,特别是在儿童等弱势群体.
- 植物性抗炎化合物1,8-Cineol已被批准用于包括CRS在内的呼吸道疾病.
研究的目的:
- 为了研究1,8-Cineol对CRS患者肠道微生物群组成的影响.
- 为了评估1,8-Cineol在肠道微生物干扰方面的安全性.
主要方法:
- 31名CRS患者的便样本在1,8-Cineol给药前后被分析.
- 16S rRNA基因下一代测序用于微生物组分析.
- 基于不相似性和分类学方法被用于评估微生物变化.
主要成果:
- 在CRS患者中,肠道微生物群显示出高度的*Bacteroides*和*Faecalibacterium*,被认为是健康肠道微生物群体的一部分.
- 1,8-cineol治疗并没有对肠道微生物群体产生重大整体干扰.
- 一个值得注意的趋势表明,在1,8-Cineol给药期间,Akkermansia muciniphila的丰富性增加了.
结论:
- 1,8-醇可以作为一种有益的补充剂,用于如CRS等炎症性疾病的当前标准治疗方法.
- 1,8-Cineol的使用不会在肠道微生物群体中造成严重的负面变化的风险.
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