在接受内镜下粘膜剖析的病例中,大结肠直肠状病变的亚粘膜纤维化
Erik Manriquez-Alegria1,2, Naohisa Yoshida3, Reo Kobayashi1
1Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Therapeutic advances in gastroenterology
|August 11, 2025
概括
结肠直肠状病变 (CSLs) 在内镜下粘膜解剖 (ESD) 期间显示的亚粘膜纤维化比腺瘤或早期癌症少. 这一发现表明CSL在ESD程序中可能有更好的结果.
科学领域:
- 胃肠病学 胃肠病学
- 内镜检查是指内镜检查.
- 在瘤学瘤学.
背景情况:
- 粘膜下纤维化是结直肠内镜粘膜下剖析 (ESD) 中不良结果的已知危险因素.
- 关于结直肠状病变 (CSL) 中纤维化存在和影响的证据有限.
研究的目的:
- 评估CSL和下纤维化之间的关联.
- 评估纤维化存在对结直肠ESD治疗结果的影响.
主要方法:
- 445例结直肠ESD病例 (2020-2024) 的回顾性队列研究.
- 损伤≥20毫米被归类为CSL或腺瘤+T1癌症.
- 纤维化,严重纤维化和ESD结局的评估.
- 多变量分析以确定与纤维化相关的因素.
主要成果:
- 与腺瘤 + T1癌症相比,CSL (72例) 的纤维化 (34.7%) 和严重纤维化 (6.9%) 显著减少 (373例;分别为48.5%和18.2%).
- 与纤维化存在相关的因素包括CSL组织学,病变大小≥40毫米和直肠位置.
- 与严重纤维化相关的因素包括病变大小≥40毫米和多形态.
结论:
- 在结直肠ESD中,CSL组织学与下纤维化有负相关性.
- 这表明基于病变组织学ESD结果的潜在差异.
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