胸前脂肪量与冠状动脉微血管功能障碍之间的关系
Tsuyoshi Ito1, Atsushi Niwa1, Masashi Yokoi1
1Department of Cardiology, Nagoya City University Graduate School of Medical Sciences Nagoya Japan.
Circulation reports
|August 11, 2025
概括
心脂肪体积 (EFV) 与没有阻塞性冠状动脉疾病 (CAD) 的个体的冠状动脉微血管功能障碍 (CMD) 有关. 这一发现表明EFV可能是评估CMD风险的有用指标.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 血管生物学 血管生物学
背景情况:
- 冠状动脉微血管功能障碍 (CMD) 是心肌缺血的一个关键因素,特别是在没有阻塞性冠状动脉疾病 (CAD) 的患者中.
- 副心脏脂肪体积 (EFV) 已与副心脏CAD和腹功能障碍有关.
- 需要进一步阐明EFV和CMD之间的特定关系.
研究的目的:
- 调查心上脂肪体积 (EFV) 和冠状动脉微血管功能障碍 (CMD) 之间的关联.
- 确定EFV是否在没有阻塞性CAD的患者中是CMD的独立预测因素.
主要方法:
- 103名没有阻塞性CAD的患者使用冠状动脉流量储备 (CFR) 和微循环阻力指数 (IMR) 评估CMD.
- 用计算机断层扫描量化心脏上脂肪体积 (EFV),并计算EFV指数.
- 使用统计分析,包括后勤回归来评估EFV指数和CMD之间的关系.
主要成果:
- 冠状动脉微血管功能障碍 (CMD) 在33%的研究队列中被确定.
- 患有CMD的患者与没有CMD的患者相比,EFV指数显著增加.
- EFV指数显示出与IMR显著的正相关性,与CFR的负相关性,并且与CMD独立相关.
结论:
- 在缺乏阻塞性冠状动脉疾病的患者中,心上脂肪体积 (EFV) 与冠状动脉微血管功能障碍 (CMD) 有显著的关联.
- 在这种人群中,EFV可以作为一种有价值的成像生物标志物来识别CMD.
相关概念视频
01:29Heart Failure II: Pathophysiology
41
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
41
01:26Coronary Artery Disease II: Pathophysiology
35
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
35
01:30Coronary Artery Disease I: Introduction
55
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
55
01:26Imbalances in Cardiac Output
1.5K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.5K
01:17Pathophysiology of Heart Failure
1.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.8K