针对恶性黑色素瘤接受免疫治疗的患者的复发性计算机断层扫描检查的辐射负担
David Girsa1,2, Marek Pasek3, Lucie Sukupova4
1Department of Radiology and Nuclear Medicine, Third Faculty of Medicine, Charles University, Faculty Hospital Kralovske Vinohrady, Prague, Czech Republic.
Quantitative imaging in medicine and surgery
|August 11, 2025
概括
接受免疫治疗的转移性恶性黑色素瘤患者的复发性计算机断层扫描 (CT) 扫描导致大多数患者的显著累积有效剂量 (CED) 超过100mSv,增加了辐射诱导的恶性瘤风险.
科学领域:
- 医疗成像医学成像
- 辐射瘤学 辐射瘤学
- 在瘤学瘤学.
背景情况:
- 计算机断层扫描 (CT) 在瘤学中对于诊断和随访至关重要.
- CT检查涉及大量的电离辐射剂量.
- 超过100mSv的有效剂量 (ED) 会增加致命恶性瘤的风险.
研究的目的:
- 在接受免疫治疗的转移性恶性黑色素瘤患者中评估复发性CT扫描的辐射负担.
- 为了确定这个患者队列中的累积有效剂量 (CED).
主要方法:
- 追溯性研究设计.
- 包括在2016年至2021年期间治疗转移性恶性黑色素瘤的54名患者.
- 个人CT检查EDs和累计有效剂量 (CED) 的回顾性计算.
主要成果:
- 患者接受了平均8次CT检查.
- 64%的患者的CED超过100mSv.
- 20%的患者的CED超过300mSv,最高为547.7mSv.
结论:
- 在这个队列中,经常性CT扫描与高累积有效剂量 (CED) 有关.
- 超过100mSv的CED与辐射诱导恶性瘤的显著风险有关.
- 在这些患者的后续护理计划中,应考虑高CED.
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