癌症中的新陈代谢和表观遗传学:走向个性化治疗
Xiaoman Zhang1, Dequan Liu1, Sulan Yin2
1Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Frontiers in endocrinology
|August 11, 2025
概括
表观遗传修饰通过改变与代谢相关的基因表达来影响癌症. 了解这种相互作用为通过饮食干预提供了针对性治疗和个性化治疗的新途径.
科学领域:
- 分子生物学分子生物学
- 癌症研究 癌症研究
- 代谢学 代谢学 代谢学
背景情况:
- 诸如DNA甲基化和基因素修饰等表观遗传机制可以调节基因表达,而不会改变DNA序列.
- 代谢途径越来越被认为是癌症表观遗传过程的关键调节者.
- 代谢和表观遗传学之间的相互作用对于癌症的发展和进展至关重要.
研究的目的:
- 系统地审查癌症发展中的代谢和表观遗传调节网络.
- 探索代谢物和表观遗传驱动因素,包括非编码RNAs (ncRNAs) 在癌症中的作用.
- 讨论针对癌症治疗的代谢-表观遗传轴的治疗策略.
主要方法:
- 对来自PubMed,Web of Science和TCGA的500多项研究进行了系统分析.
- 包括人类细胞系实验,动物模型,临床队列研究和生物信息学分析.
- 专注于机理学研究,奥米克分析和翻译研究,包括来自SW480,MCF7和APC突变小鼠的数据.
主要成果:
- 参与葡萄糖/脂质代谢和能量生产的基因受到表观遗传调节.
- 代谢物作为表观遗传修饰的共酶或基质.
- 糖脂代谢重编程,微生物代谢物和ncRNA是癌症的关键表观遗传驱动因素.
结论:
- 代谢和表观遗传学之间的交叉交流为识别新型癌症标提供了机会.
- 饮食干预可以调节用于个性化癌症治疗的表观遗传标记.
- 针对新陈代谢与表观遗传学相互作用提供了克服治疗药物耐药性的潜在策略.
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