乳酸菌和双菌在过敏性鼻炎中的有效性:叙述性综述
Tejaswi Mishra1, Ksbs Krishna Sasanka1, Sree Sudha Ty2
1Otorhinolaryngology-Head and Neck Surgery, All India Institute of Medical Sciences, Deoghar, Deoghar, IND.
Cureus
|August 11, 2025
概括
像Lactobacillus和Bifidobacterium这样的益生菌显示出通过调节免疫反应来管理过敏性鼻炎 (AR) 的前景. 需要进一步的研究来证实菌株特异性的疗效,并优化治疗方案的这种慢性疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 过敏性鼻炎 (AR) 是一种慢性鼻炎,目前的治疗方法往往无法充分治疗.
- 肠肺轴和微生物群在免疫力中的作用表明益生菌可以作为补充性AR治疗.
- 乳杆菌和Bifidobacterium是具有免疫调节潜力的关键益生菌属.
研究的目的:
- 审查目前关于乳酸菌和Bifidobacterium对过敏性鼻炎的有效性的证据.
- 综合从临床前和临床研究中关于在AR中益生菌使用的研究结果.
- 确定基于益生菌的AR管理中的差距和未来研究方向.
主要方法:
- 关于临床前 (小鼠模型) 和临床研究的叙述性综述.
- 对研究的分析,重点是AR中的Lactobacillus和Bifidobacterium属.
- 包括评估益生菌对AR症状和生活质量影响的元分析.
主要成果:
- 临床前研究表明,特定的益生菌菌株可以通过调节细胞因子和T细胞活性来减少过敏反应.
- 临床数据表明,选择的菌株可以改善AR症状和成人和儿童的生活质量.
- 分析支持益处,但强调了研究设计,菌株,剂量和持续时间的显著异质性.
结论:
- 乳酸菌和Bifidobacterium显示出作为过敏性鼻炎的辅助疗法的潜力.
- 证据是有希望的,但受研究变异和方法方面的弱点限制.
- 更严格的,针对特定菌株的试验对于确定最佳使用和确认免疫调节机制至关重要.
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