相关实验视频

Updated: Sep 11, 2025

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
11:22

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

Published on: August 12, 2019

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设计和合成一个化学多样性,类似的DNA编码库从序列胺合的设计和合成

Cameron E Taylor1, Grace Roper1, Rhianna Young2

  • 1Cancer Research Horizons Newcastle Drug Discovery Unit, Chemistry, School of Natural and Environmental Sciences, Newcastle University Bedson Building Newcastle upon Tyne NE1 7RU UK mike.waring@ncl.ac.uk.

RSC medicinal chemistry
|August 11, 2025
PubMed
概括

我们使用简单的化学方法开发了DNA编码图书馆 (DEL),创造了30万个和300万个成员的图书馆. 这些DEL对于药物发现查是有效的,并且可供研究人员使用.

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相关概念视频

Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
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