慢性淋巴细胞淋巴瘤由Mycobacterium Avium和Scedosporium Apiospermum复杂化
Dhiran Sivasubramanian1, Bala Vignesh Kalyanasundaram2, Nithish Nanda Palanisamy3
1Department of Cardiology, Children's Hospital of Philadelphia, Philadelphia, USA.
European journal of case reports in internal medicine
|August 11, 2025
概括
本病例报告详细介绍了一例罕见的Mycobacterium avium和Scedosporium apiospermum双重感染,该病例发生在一名慢性淋巴细胞白血病 (CLL) 患者身上. 它强调需要对免疫功能低下个体的机会性感染保持警.
科学领域:
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 慢性淋巴细胞白血病 (CLL) 是西方国家最常见的成人白血病.
- 机会性感染在CLL患者,特别是那些接受化疗的患者中带来了重大管理挑战.
- 免疫受损的个体容易患上由病原体引起的严重疾病,如Mycobacterium avium和Scedosporium apiospermum.
研究的目的:
- 在患有慢性淋巴细胞白血病的患者中报告一种罕见的同时感染Mycobacterium avium和Scedosporium apiospermum的病例.
- 突出免疫功能低下患者双重机会性感染的诊断和管理复杂性.
- 为了强调CLL中异常病原体的高怀疑指数的重要性.
主要方法:
- 一个78岁的男性患有CLL正在接受化疗的病例报告.
- 临床表现包括口腔病变和非生产性咳,最初被误诊为肺炎.
- 诊断调查显示与Mycobacterium avium和Scedosporium apiospermum的同时感染.
主要成果:
- 患者出现了暗示肺炎的症状,但被发现患有罕见的共感染.
- 由于活性肺炎,化学疗法暂时停止,以改善白细胞计数.
- 针对Mycobacterium avium复合体启动了抗菌疗法;由于缺乏侵入性真菌感染证据,因此暂停了抗菌疗法.
结论:
- 在CLL患者中,Mycobacterium avium和Scedosporium apiospermum的共存突出了感染性并发症的范围.
- 多学科方法和个性化,基于证据的治疗策略对于管理这些复杂的病例至关重要.
- 警罕见的感染,即使有异常或轻度症状,对于患有CLL的免疫功能低下患者至关重要.
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