在四十年的时间里,马匹医院的体外抗菌素耐药性的演变
Antoine Symoens1, Marie-Lou Gauthier1, Louise Paillette1
1Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, 3200, rue Sicotte, Saint-Hyacinthe (Québec) J2S 7C6 (Symoens, Paillette, Allano, Lavoie, Leclère); Centre de diagnostic vétérinaire de l'Université de Montréal (CDVUM), 3220, rue Sicotte, Saint-Hyacinthe (Québec) J2S 2M2 (Gauthier).
概括
马类细菌分离物中的抗菌素耐药性增加了,特别是对临界重要的抗生素,如恩洛夫洛克萨. 然而,青素对某些细菌仍然有效,强调需要持续监测和有针对性的治疗策略.
科学领域:
- 兽医微生物学 兽医微生物学
- 抗微生物耐药性研究研究
- 马的健康 马的健康
背景情况:
- 抗菌素耐药性 (AMR) 是一个日益严重的全球问题,影响人类和动物的健康.
- 在兽医环境中监测AMR模式对于指导治疗决策和公共卫生战略至关重要.
- 马类细菌病原体表现出不同的耐药性,需要定期更新它们的敏感性模式.
研究的目的:
- 在转诊医院从马匹中分离出来的关键细菌的当前抗菌素耐药性模式的记录.
- 为了比较最近的耐药性数据 (2020-2022年) 与同一机构跨越数十年的历史数据.
- 为了确定马匹细菌分离物中抗微生物敏感性和耐药性的趋势.
主要方法:
- 从马体病例中分离出来的细菌被测试了使用Kirby-Bauer方法的抗菌敏感性.
- 在2020-2022年期间,共进行了340次敏感性测试.
- 数据使用基平方测试进行统计分析,以寻找趋势,其次是双对的费舍尔测试与邦费罗尼校正,并与1986-1988,1996-1998年和2007-2013年的历史数据进行比较.
主要成果:
- 在6种研究的细菌物种中,在5种细菌物种中观察到抗菌素耐药性的增加.
- 对*大肠杆菌*,*伪虫*种类,*虫*种类和葡萄球菌的耐药性显著增加.
- 在Enterobacter* spp.中记录了对ceftiofur的抗药性增加. 和葡萄球菌,而对安培和青素的耐药性在*Actinobacillus* spp.下降.
结论:
- 马类细菌分离体对抗生素的耐药性越来越强,这对人类医学至关重要.
- 青素仍然是一个可行的第一线治疗 *Actinobacillus* spp. 和 *Streptococcus equi* 分种. 在研究区域的 * zooepidemicus * .
- 对马群中抗菌素耐药性的持续监测对于有效治疗和控制感染至关重要.
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