潮呼吸肺功能,呼出的氧化和气道过敏反应之间的相关性 0-3岁的儿童怀疑喘
Jiangjiao Qin1,2, Fangjun Liu1,2, Ting Wang2,3
1Department of Pulmonary Function, Children's Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in pediatrics
|August 11, 2025
概括
分数呼出的氧化 (FeNO) 和潮呼吸的肺功能参数可以预测疑似喘的幼儿的呼吸道过敏反应 (AHR). 包括FeNO,呼吸速率和年龄在内的综合措施,在预测AHR严重程度方面具有很高的准确性.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统医学 呼吸系统医学
- 喘研究 喘研究
背景情况:
- 呼吸道过敏反应 (AHR) 是喘的标志,但在婴儿和幼儿 (0-3岁) 中对其进行评估是具有挑战性的.
- 在这个年龄组中确定可靠的非侵入性AHR标志物对于早期诊断和管理至关重要.
研究的目的:
- 探索潮呼吸肺功能参数和分数呼出的氧化 (FeNO) 与0-3岁怀疑患有喘的儿童的AHR程度之间的相关性.
- 评估这些参数对AHR的预测效果.
主要方法:
- 临床数据的回顾性分析,潮呼吸肺功能参数和FeNO水平从818名儿科患者 (0-3岁) 接受甲胆挑战测试 (MCT).
- 使用顺序多类后勤回归和ROC曲线分析来识别影响AHR的因素并评估预测准确性.
主要成果:
- FeNO,呼吸速率 (RR) 和特定的呼气流量 (PTEF/TEF25) 与AHR严重程度正相关,而年龄与AHR严重程度负相关.
- 在预测AHR时FeNO表现出合理的准确性 (AUC=0.774),AHR为8mg/ml甲,截止值为14ppb.
- 综合参数 (FeNO,RR,PTEF/TEF25,年龄) 在0.5mg/ml甲中显示出高预测精度 (AUC=0.847).
结论:
- 目前的呼吸道炎症和阻塞有效地预测幼儿的AHR.
- FeNO,RR,PTEF/TEF25和年龄是疑似喘的0-3岁儿童中AHR严重程度的有价值预测指标.
- FeNO>14 ppb是AHR的独立因素,并且组合的参数提高了预测效率.
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