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Updated: Sep 11, 2025

In vivo Dual Substrate Bioluminescent Imaging
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In vivo Dual Substrate Bioluminescent Imaging

Published on: October 11, 2011

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使用单链生物发光探针对联体驱动PPAR活动进行成像.

Sung-Bae Kim1, Tadaomi Furuta2, Genta Kamiya3

  • 1Environmental Management Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 16-1 Onogawa, Tsukuba 305-8569, Japan.

ACS omega
|August 11, 2025
PubMed
概括

研究人员开发了一个新的分子成像平台,使用生物发光探针来监测核受体 (NR) 活动. 这种系统,以PPARγ为例,显示了研究NR相关的信号通路在新陈代谢和恒温的前景.

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Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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