具有非正常ARF-AoS发生率的VisR超声波检查了横向同位素材料中的Shear和Young弹性模块
Sabiq Muhtadi1, Caterina M Gallippi1
1Joint Department of Biomedical Engineering, The University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC 27599 USA North Carolina State University (NCSU), Raleigh, NC 27695 USA.
IEEE open journal of ultrasonics, ferroelectrics, and frequency control
|August 11, 2025
概括
这项研究引入了一种使用粘弹性反应 (VisR) 测量组织弹性的新超声波方法. 该技术分析了弹性的变化,使用不同的超声波角度来描述像肌肉这样的异性质组织.
科学领域:
- 生物医学超声波 生物医学超声波
- 生物物理学的生物物理.
- 组织力学 组织力学
背景情况:
- 粘弹性响应 (VisR) 超声波评估异型材料中的剪切弹性模块.
- 目前的方法仅限于声辐射力 (ARF) 与对称轴 (AoS) 的正常发生.
- 在异构组织中询问的弹性模块仍然是一个挑战.
研究的目的:
- 评估VisR超声波在异构介质中探测弹性模块的潜力.
- 调查不同的ARF发生角度是否可以提供更全面的弹性信息.
- 建立一种用于表征组织生物力学的新方法.
主要方法:
- 使用不同ARF-AoS发生角度的体实验.
- 监测了VisR衍生的相对弹性 (ΔRE) 与ARF-AoS发生角度的百分比变化.
- 使用肉和牛肉肌肉组织验证的实体研究结果.
主要成果:
- 在正常发生时的相对弹性 (RE) 仅与纵切模量 (μL) 相对应.
- RE (ΔRE) 的变化显示出强有力的线性相关性 (0.97-0.99) 与纵切与Young模块 (μL/EL) 的比率.
- ΔRE与ARF-AoS发生角度的斜率在统计学上区分了具有微妙差异的μL/EL比率和分化的肌肉组织的材料.
结论:
- ΔRE 与 ARF-AoS 发生角的变化速率可以作为异型组织的新生物标志物.
- 这种方法提供了一种半量化方法来表征组织特性.
- 潜在的应用包括鉴定脏,骨肌肉和乳腺组织的特征.
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