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大麻二醇使人类中性粒细胞偏向于促进癌症的表型

Mona Khoury^1,2, Yuxiang Hong^1,2,3, Dayana Blokon-Kogan^4,5

¹Cancer Center, Emek Medical Center, Afula, Israel.

Frontiers in immunology

|August 11, 2025

概括

大麻 (CBD) 可能通过改变中性粒细胞进入促进癌症的状态来促进癌症生长. 这种免疫转移抑制了抗瘤T细胞反应,对使用CBD补充剂的癌症患者构成潜在风险.

科学领域:

免疫学免疫学免疫学
癌症生物学癌症生物学
药理学药理学是指药理学的学科.

背景情况:

Cannabidiol (CBD) 越来越多地用于缓解症状,但其对免疫系统和癌症的影响尚不清楚.
越来越多的CBD消费需要对其潜在的益处和风险进行研究,特别是在癌症患者等弱势群体中.

研究的目的:

研究大麻素 (CBD) 对人类中性粒细胞功能的影响及其随后对癌细胞和T细胞的影响.
确定CBD是否影响中性粒细胞两极分化及其对抗瘤免疫力的影响.

主要方法:

人类中性粒细胞暴露于CBD,并评估它们的功能 (氧化突发,细胞因子产生,杀死细菌).
研究了CBD受条件介质对癌细胞增殖,迁移和血管生成的影响.
用中性粒细胞/T细胞共同培养来评估CBD对T细胞增殖和激活的影响.

主要成果:

CBD诱导中性粒细胞采用类似N2的,促进癌症的表型,其特点是氧化爆发减少和改变细胞因子配置.
接受CBD治疗的中性粒细胞增强了癌细胞的增殖,迁移,血管生成和PD-L1表达.
通过CBD刺激的中性粒细胞抑制了T细胞的增殖,这表明抗瘤免疫力可能受到损害.

结论:

大麻素 (CBD) 通过促进亲瘤原生的免疫环境,可能对癌症患者构成风险.
进一步的研究至关重要,以阐明CBD在癌症和免疫疗法的背景下对免疫效应和信号通路的了解.

关键词:

网症 (NETosis) 是一种疾病.大麻醇 (CBD) 是一种细胞因子分泌细胞因子分泌中性粒细胞活化激活主要的中性粒细胞.

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