在注射抗血管内皮生长因子后的眼内压力,在眼睛中注射了由Pseudoxanthoma Elasticum引起的矿物化Bruch膜
Kristin Raming1, Isabel Saltenberger1, Jonathan Meinke1
1Department of Ophthalmology, University of Bonn, Bonn, Germany.
Investigative ophthalmology & visual science
|August 11, 2025
概括
内抗VEGF注射在患有Pseudoxanthoma elasticum (PXE) 的患者中暂时增加眼内压力 (IOP),比对照患者更多. 这表明PXE患者可能受益于注射前的IOP降低策略.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 血管生物学 血管生物学
背景情况:
- 伪松弹性 (PXE) 是一种罕见的遗传疾病,影响皮肤,眼睛和心血管系统的弹性纤维.
- 血管状条纹是PXE的常见眼部表现,增加了诸如冠状腺新血管化等并发症的风险.
- 抗VEGF疗法经常用于管理与PXE相关的并发症.
研究的目的:
- 为了评估PXE患者的抗VEGF注射后眼内压 (IOP) 的急性变化.
- 为了将PXE患者的IOP反应与其他视网膜疾病的对照患者的IOP反应进行比较.
主要方法:
- 20个PXE患者的眼睛和30个对照眼睛接受了静脉内抗VEGF注射.
- 眼内压力 (IOP) 在基线和注射后1,5分钟和15分钟被测量.
- 使用注射后IOP衰变曲线的时间常数 (tau) 作为主要结果指标.
主要成果:
- 在注射后,眼内压 (IOP) 在两组中都显著增加.
- 与对照组 (7.6分钟) 相比,PXE患者的中位时间常数 (tau) 较长 (8.6分钟),表明恢复到基线IOP (P=0.02) 的速度较慢.
- 经过PXE诊断,血管条长度,先前的短暂视力丧失,外周动脉疾病和先前的抗VEGF注射与较高的tau值有关.
结论:
- 与对照组相比,PXE患者在抗VEGF注射后经历了长时间的IOP升高.
- 这些发现表明,PXE患者可能在注射后对IOP波动的脆弱性增加.
- 对于接受频繁抗VEGF治疗的PXE患者,研究注射前的IOP降低措施的临床试验是有必要的.
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