心肺移植:过去和现在. 一个系统的审查
Ryaan El-Andari1, Nicholas M Fialka1, Abrar Alam2
1Division of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
Clinical transplantation
|August 11, 2025
概括
集体心肺移植 (HLTx) 在过去50年里发生了显著的进化. 虽然现在不太常见,但HLTx仍然适用于特定的末期心脏和肺部疾病,近期的生存率有所改善.
科学领域:
- 心胸外科手术 心胸外科手术
- 移植医学 移植医学
- 肺部和心血管疾病
背景情况:
- 整体心肺移植 (HLTx) 已经是治疗末期心肺疾病的方法了五十年.
- 在此期间,HLTx程序和患者管理方面取得了重大进展.
研究的目的:
- 进行心肺移植 (HLTx) 的系统审查.
- 描述接受HLTx.的患者的演变和结果.
主要方法:
- 使用PubMed和Embase数据库进行了全面的文献搜索.
- 选了1513篇文章,其中29篇最终被纳入了这个系统审查.
主要成果:
- 在2000年之前,HLTx更常见于囊性纤维化,艾森门格综合征和肺高血压.
- 2000年后,HLTx更频繁地用于肺高血压和先天性心脏病,不太重视囊性纤维化.
- 在最近的研究中,短期死亡率有所下降,而当代报告中出现的长期生存数据.
结论:
- 心肺移植在指示,疗法和结果方面经历了相当大的进化.
- 尽管与早期心胸移植相比频率下降,但HLTx仍然适用于特定患者群体.
- 持续报告HLTx患者管理和结果的趋势对于程序的持续改进至关重要.
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