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相关概念视频

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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Regression Toward the Mean01:52

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Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
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相关实验视频

Updated: Sep 11, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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一项前性研究,以确定三季度特定的甲状腺功能参考间隔.

Li-Hsin Pan1, Chang-Ching Yeh2,3, Shun-Jie Yang4

  • 1Division of Endocrinology and Metabolism, Department of Medicine, Zhongxiao Branch, Taipei City Hospital, Taipei, 115006, Taiwan.

Journal of endocrinological investigation
|August 11, 2025
PubMed
概括
此摘要是机器生成的。

对于准确的甲状腺疾病诊断,为怀孕的台湾妇女建立三个月特定的甲状腺功能测试 (TFT) 参考间隔至关重要. 这项研究提供了这些重要间隔,并详细介绍了整个怀孕期间甲状腺激素和抗体的变化.

关键词:
怀孕 怀孕 怀孕时间怀孕 怀孕 怀孕 怀孕参考间隔 的参考间隔.台湾 台湾 台湾 台湾甲状腺功能测试测试甲状腺功能测试

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科学领域:

  • 内分泌学 在内分泌学.
  • 生殖医学 生殖医学
  • 临床化学 临床化学

背景情况:

  • 在怀孕期间准确评估甲状腺功能是防止甲状腺疾病误诊的必要条件.
  • 确定甲状腺功能测试 (TFT) 的特定人群参考间隔对于解释孕妇结果至关重要.
  • 甲状腺激素水平和抗体状态在整个妊娠期间自然发生变化.

研究的目的:

  • 确定怀孕台湾妇女TFTs的三个月特定的参考间隔.
  • 在这群人群中,分析怀孕期间甲状腺激素和抗甲状腺抗体的变化.
  • 为准确诊断怀孕台湾妇女甲状腺疾病提供基础.

主要方法:

  • 对台湾209名孕妇 (2019-2022) 的前性研究.
  • 排除具有阳性抗甲状腺抗体或使用甲状腺药物的参与者.
  • 使用电化学发光免疫测试,每季度测量TFTs (TSH,自由T4,总T4,自由T3,总T3) 和抗体.
  • 通过尿液度评估状态.

主要成果:

  • 研究群体表现出足够的状态 (尿液中位:162.5μg/L).
  • 甲状腺刺激激素 (TSH) 水平在第一季度明显低于第二和第三季度.
  • 在整个怀孕期间,自由T4和自由T3水平下降,而总T4和抗甲状腺抗体水平在第一季度较高.

结论:

  • 对于孕妇来说,TFTs的三个月特定的参考间隔是必不可少的,特别是在使用罗氏试验时.
  • 这项研究为台湾孕妇提供了第一个基于人口的,三个月特定的TFT参考间隔.
  • 在怀孕期间准确解释甲状腺功能需要考虑妊娠阶段和特定人群的数据.