结石事件和ESKD发生率在患有来自各种肠道病因的肠道过氧症患者中
Ryan Tatton1, Stephen O'Neill1, Deondre Jordan2
1Mayo Clinic, Scottsdale, AZ, USA.
Kidney360
|August 11, 2025
概括
肠道高氧流症 (EH) 患者根据病因表现出不同的脏风险. 结构性肠道吸收不良 (SIM) 和外分胰腺功能不充分 (EPI) 与更多的结石和末期病 (ESKD) 相关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 肠道高氧化尿 (EH) 是氧化酸腎病和病的重要危險因素.
- 了解EH的各种原因对于管理相关的并发症至关重要.
研究的目的:
- 为了比较患者的特征和尿液代谢概况在一个队列与肠道高氧化尿 (EH) 的各种原因.
- 在EH患者的随访期间评估结石和末期病 (ESKD) 事件率.
主要方法:
- 确定了患有尿氧酸水平升高 (>40毫克/24小时) 和已知肠道诊断的成年患者.
- 包括的诊断包括:炎症性肠病,外分胰腺功能不全 (EPI),腹腔疾病,结构性肠道吸收不良 (SIM) 或吸收不良的腹手术.
- 评估了结石和ESKD的发生率和累积发病率.
主要成果:
- 最常见的EH原因是吸收不良的腹腔外科手术 (64%).
- 患有结构性肠道吸收不良 (SIM) 的患者表现出更高的尿氧酸和更低的尿酸.
- SIM和EPI组的结石发病率最高,而SIM显示ESKD发病率最高.
结论:
- 患者特征,尿液代谢风险因素和EH患者的结局存在显著的异质性.
- 患有SIM和EPI的患者面临更高的结石风险,患有SIM的患者ESKD发病率增加.
- 需要进一步的研究,以了解EH中脏并发症的自然史和风险因素,以指导干预.
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