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Updated: Sep 11, 2025

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阿托瓦奎-普罗瓜尼尔和降低消化系统癌症的风险:一种与毒素的联系

Ariel Israel^1,2, Sarah Israel³, Abraham Weizman⁴

¹Leumit Research Institute, Leumit Health Services, Tel Aviv, Israel.

|August 11, 2025

概括

阿托瓦昆-普罗瓜尼尔 (A-P) 的使用与较低的消化道癌症风险有关. 寄生虫Toxoplasma gondii被确定为结直肠癌的重要危险因素.

科学领域:

胃肠病学胃肠病学
传染性疾病传染性疾病
在瘤学瘤学.

背景情况:

微生物病原体越来越多地与消化道癌症的发展有关.
一种抗疟疾药物阿托瓦昆-普罗古安尼尔 (A-P) 已显示出降低结直肠癌 (CRC) 风险的潜力.
特定寄生虫的作用,如Toxoplasma gondii,在消化系统癌症中需要进一步调查.

研究的目的:

调查AP使用与消化道癌症发病率之间的关联.
探索Toxoplasma gondii在CRC发展中的潜在作用.
评估A-P对消化系统癌症的化学预防作用.

主要方法:

使用TriNetX美国协作网络进行的回顾性队列研究,涉及超过10万个人.
1: 1匹配的AP使用者对其他药物的控制.
对于发生的消化道癌症的Cox比例危险模型和对T. gondii丰富度的便样本的元基因组分析.

主要成果:

在不同年龄组中,A-P使用与消化系统癌症发病率降低显著相关 (HRs 0.49-0.53,p < 0.001).
A-P的保护作用扩展到胰腺癌 (HR范围为0.50-0.72).
T. gondii对CRC具有高度的歧视性 (OR 18.2,p = 2.3 × 10−22),在22.6%的CRC病例和1.6%的对照中发现.

结论:

T. gondii可能是消化道癌症的低估的微生物风险因素.
A-P显示了对消化系统癌症的潜在化学预防性质,可能是通过其抗寄生虫作用.
需要进一步的前性研究来证实AP的预防潜力.

关键词:

结肠直肠癌是一种癌症.这种毒性淋巴细胞 (Toxoplasma gondii) 是这是一种atovaquone.预防癌症预防癌症电子健康记录是电子健康记录.转基因组学是指转基因组学.我们的微生物群.胰腺癌是一种癌症.

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