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睡眠呼吸暂停对周血管扩散和认知的影响:为期四年的前性队列研究

Min-Hee Lee¹, Woo-Jin Lee², Seung-Ku Lee¹

¹Korea University College of Medicine, Institute of Human Genomic Study, Seongbuk-gu, Seoul, Korea (the Republic of).

American journal of respiratory and critical care medicine

|August 11, 2025

概括

阻塞性睡眠呼吸暂停 (OSA) 与周围血管扩散性降低有关,这是大脑液流的标志物. 这种障碍有助于记忆力下降,表明从OSA到认知障碍的途径.

科学领域:

神经成像是一种神经成像.
睡眠医学睡眠医学
认知神经科学认知神经科学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 是一种可能对周血管扩散性产生负面影响的疾病.
周血管扩散性是淋巴功能的一个潜在生物标志物,与认知衰退有关.

研究的目的:

检查OSA对认知功能和周围血管扩散性的长期影响.
确定周血管扩散率的变化是否介导了OSA和认知表现之间的联系.

主要方法:

一个由1110名参与者组成的社区队列接受了多睡眠学,在周围血管空间 (DTI-ALPS) 进行扩散张力成像,并在基线和四年随访时进行认知测试.
参与者根据OSA严重程度 (呼吸暂停-呼吸暂停指数) 进行分类,并纵向跟踪OSA状态变化.
根据各种健康和生活方式因素调整的统计模型,分析了随时间变化的DTI-ALPS和认知指标.

主要成果:

较高的呼吸暂停-呼吸暂停指数 (AHI) 与较低的DTI-ALPS相关,表明周围血管扩散性降低.
OSA状态的恶化与DTI-ALPS的最显著下降有关.
在DTI-ALPS的改善与增强的视觉记忆有关,包括立即回忆,延迟回忆和识别.
在DTI-ALPS的变化中介于AHI的变化和视觉记忆功能的变化之间的关系.

结论:

OSA的严重程度与周围血管扩散性受损有关.
改变周围血管扩散性与记忆功能的变化有关.
这些发现表明,OSA通过对周血管流体动态的影响影响认知产生影响的机制.

关键词:

认知功能认知功能扩散张力成像扩散张力成像淋巴系统淋巴系统阻塞性睡眠呼吸暂停 (SOP) 是一种阻塞性睡眠暂停.

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