炎症和肥胖与肺高血压相关,但与不同的结果相关
Eckart De Bie1,2,3, Priscilla Correa-Jaque4, Rowena Jones5
1University of Cambridge, Victor Phillip Dahdaleh Heart & Lung Research Institute, Cambridge, Cambridgeshire, United Kingdom of Great Britain and Northern Ireland.
细胞C反应蛋白 (CRP) 水平和体重指数 (BMI) 识别了肺高血压 (PH) 的不同患者群体. 虽然炎症 (CRP) 与更糟糕的结果有关,但肥胖 (BMI) 显示PH患者的生存率有所改善.
科学领域:
- 心血管研究研究心血管研究
- 肺部医学 肺部医学
- 炎症和免疫学 炎症和免疫学
背景情况:
- 炎症是所有类型的肺高血压 (PH) 的已知因素.
- 常见的炎症标志物C-反应蛋白 (CRP) 需要在PH进行进一步的研究.
- 这项研究旨在确定CRP是否有助于PH临床内型化和结果预测.
研究的目的:
- 研究C反应蛋白 (CRP) 在肺高血压 (PH) 临床内型化中的作用.
- 评估CRP水平与PH患者的功能和死亡结果的关联.
- 探索CRP,体重指数 (BMI) 和PH的临床特征之间的关系.
主要方法:
- 使用时间序列集群分析了纵向CRP水平.
- 来自三个独立队列 (n=10,301) 的临床数据被用于验证.
- 通过回归模型和多omics分析,研究了与功能和死亡结果的关联.
主要成果:
- 出现了两个稳定的CRP集群:低 (中位数为2 mg/l) 和高 (中位数为6.5 mg/l).
- 高CRP集群显示出更高的BMI,右心房压 (RAP) 和减少6分钟的步行距离 (6MWD).
- 较高的BMI与改善的生存率和较低的肺血管阻力 (PVR) 相相关,尽管与CRP有关.
结论:
- 在所有原因的PH中,CRP和BMI定义了不同的表型,临床结果不同.
- 炎症和肥胖是PH临床试验设计的关键表型.
- 了解炎症和肥胖对结果的影响对于PH的临床实践至关重要.
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