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在抗核抗体阴性的情况下,是否需要要求对可提取核抗原的抗体进行测试?
1Department of Immunology, Ankara Bilkent City Hospital, Ankara, Turkey.
Scandinavian journal of clinical and laboratory investigation
|August 11, 2025
概括
同时进行抗核抗体 (ANA) 和可提取核抗原 (ENA) 测试通常是不必要的. 在负面的ANA后减少ENA测试可以提高合理的测试选择并降低成本.
科学领域:
- 免疫学 免疫学 免疫学
- 临床化学 临床化学
- 类风湿病学 类风湿病学
背景情况:
- 不适当的实验室测试请求有助于提高利用率.
- 同时订购抗核抗体 (ANA) 和可提取核抗原 (ENA) 测试是常见的.
研究的目的:
- 调查同时进行ANA和ENA测试的频率.
- 在ANA结果为阴性时评估ENA测试的必要性,与合理测试选择标准保持一致.
主要方法:
- 来自土耳其第三级医院的两年数据的回顾性队列分析.
- 对ANA,ENA和临床数据的检查,对患者呈阴性ANA,但呈阳性ENA的结果.
主要成果:
- 在2279个负面的ANA测试中,16.2%显示了阳性ENA结果.
- 在307名具有阴性ANA/阳性ENA和临床数据的个人中,7.4% (23名患者) 新诊断患有ANA相关的类风湿性疾病 (AARD).
- 在不一致的ANA/ENA结果中,抗Ro52,抗DFS70和抗Jo-1是最常见的自身抗体.
结论:
- 结果支持在负面ANA测试后减少ENA测试.
- 增加ENA测试应保留给呈阳性ANA或明显临床迹象的病例.
- 这种方法可以尽量减少不准确的测试请求,减少医疗保健支出,并防止不必要的患者评估.
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