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Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
在新鲜周期和可选结周期中,卵巢刺激协议
Ioannis E Messinis1, Christina I Messini1, George Anifandis1,2
1Department of Obstetrics and Gynaecology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
在体外受精 (IVF) 的卵巢刺激协议在新鲜胚胎移植和选择性冷周期之间有所不同. 结所有周期避免OHSS风险,并且可能不需要预防LH激增,与新鲜周期不同.
科学领域:
- 生殖医学 生殖医学
- 在体外受精 (IVF)
- 内分泌学 在内分泌学.
背景情况:
- 在IVF中新鲜的胚胎移植历来存在卵巢过度刺激综合征 (OHSS) 的风险.
- 玻璃化技术的进步使卵细胞和胚胎的冷保存得以成功,转向冷胚胎移植的做法.
- 选择性结所有循环为新鲜转移提供了替代方案,减轻了OHSS风险.
研究的目的:
- 审查目前在IVF中的卵巢刺激策略.
- 要突出新鲜和选择性冷全部胚胎转移周期之间的刺激方法的差异.
- 讨论在结周期中预防LH激增的必要性.
主要方法:
- 关于IVF卵巢刺激的当前文献的叙述性综述.
- 新鲜胚胎移植与可选冷周期之间的协议的比较.
- 对卵细胞产量和OHSS风险因素的分析.
主要成果:
- 选择性结全周期消除了OHSS风险,并且可能没有对卵细胞产量的上限.
- 新鲜胚胎移植周期需要优化卵细胞数量以防止OHSS.
- 孕激素可能会在结周期中取代GnRH对抗剂,但LH激增预防的必要性仍在争论中.
结论:
- 卵巢刺激方案应根据新鲜和结所有试管婴儿周期量身定制.
- 在选择性结周期中LH激增预防的作用需要进一步研究.
- 玻璃化对试管婴儿协议产生了重大影响,提高了安全性和灵活性.
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