身体健康,生物衰老和健康的长寿
Ziyuan Chen1, Paul James Collings1, Mengyao Wang1
1School of Public Health, The University of Hong Kong Li Ka Shing Faculty of Medicine, Pokfulam, Hong Kong.
Journal of the American Medical Directors Association
|August 11, 2025
概括
保持心肺健康 (CRF) 和肌肉力量可以抵消加速生物衰老的风险. 较高的健身水平可以缓解过早的健康周期终结,促进长寿.
科学领域:
- 老年学是指老年学的学科.
- 运动生理学 运动生理学
- 衰老的生物标志物
背景情况:
- 身体健康,包括心肺健康 (CRF) 和肌肉力量,与降低疾病风险和改善健康结果有关.
- 结合CRF和肌肉力量对缓解加速生物衰老和促进健康长寿的综合影响尚未完全理解.
研究的目的:
- 调查心肺呼吸能力 (CRF) 和肌肉力量是否可以改变加速生物衰老和健康寿命过早终止之间的关联.
- 确定体能在生物衰老的背景下发挥的作用及其对健康的影响.
主要方法:
- 一项前性观察性研究,涉及来自英国生物银行的46,481名参与者.
- 通过自行车协议评估心脏呼吸能力 (CRF);使用手动力计测量肌肉力量.
- 生物衰老量化通过PhenoAge (基于9个生物标志物和时间年龄),并计算了年龄加速 (PhenoAgeAccel). 健康长寿终结定义为8个主要健康事件或死亡.
主要成果:
- 高CRF和肌肉强度单独与健康周期终结风险显著降低相关 (分别为10%和13%).
- 在PhenoAgeAccel和CRF和肌肉力量之间观察到显著的添加相互作用,与肌肉力量的多重相互作用.
- 加快的生物衰老在低CRF和肌肉强度的个体中构成最高风险,但这种风险被高健身水平部分抵消.
结论:
- 改善心肺呼吸能力 (CRF) 和肌肉力量可以抵消与加速生物衰老相关的过早健康周期终止的风险增加.
- 个性化健身干预应考虑生物衰老速度,以优化健康寿命.
- 公共卫生倡议应侧重于促进心肺和肌肉健康,以应对与年龄相关的健康风险.
相关概念视频
The Effect of Aging on Tissues
2.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.4K
Aging
182
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
182
Lifestyle Factors and Health
126
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
126
Mitochondria
14.9K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
14.9K
Longitudinal Research
12.5K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.5K
Bone Disorders
3.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.9K


