在晚期子宫内发育和哺乳期接触:对男性生殖功能的长期影响
Ana Priscila Gomes-Silva1, Paloma da Cunha de Medeiros1, Laís Nogueira da Silva1
1Laboratory of Experimental Toxicology - LATOEX, Universidade Federal de Sao Paulo, Instituto do Mar, Carvalho de Mendonça, 144, Santos 11070-100, Sao Paulo, Brazil.
Environmental toxicology and pharmacology
|August 11, 2025
概括
在发育过程中接触 (Mn) 会损害雄性大鼠的生殖功能. 这项研究发现,会导致氧化损伤,改变精子发育,降低关键激素水平,影响生育能力.
科学领域:
- 生殖毒理学 生殖毒理学
- 环境健康 环境健康
- 发展生物学 发展生物学
背景情况:
- (Mn) 是一种必要的微量元素,但过度暴露可能是有毒的.
- 产前和产后早期的发育是生殖系统成熟的关键窗口.
- 了解Mn对男性生殖健康的长期影响对于公共健康至关重要.
研究的目的:
- 调查发育性暴露对雄性大鼠生殖参数的慢性影响.
- 评估Mn诱导的氧化应激和生殖器官的组织学变化.
- 评估Mn对生殖激素水平和精子生成的影响.
主要方法:
- 怀孕的老鼠从13号妊娠日到15号哺乳日暴露于盐水 (对照),9毫克/公斤MnCl2或90毫克/公斤MnCl2.
- 男子后代在出生后的第50天和第90天被评估.
- 评估包括氧化损伤标志物,生殖细胞计数,丸组织学,皮质组织学和血清激素水平 (LH,FSH).
主要成果:
- 接触导致生殖细胞的氧化损伤,并增加了酸性生殖细胞.
- 在暴露于Mn的老鼠中观察到组织学变化,包括生殖表皮脱落和退化.
- 精子生成动力学受到干扰,白化激素 (LH) 和卵泡刺激激素 (FSH) 的水平降低.
结论:
- 在老鼠的发育过程中,接触会对雄性生殖系统造成长期严重的损害.
- 由Mn引起的氧化应激,组织学变化和荷尔蒙失衡会损害精子生成和精子质量.
- 这些发现凸显了在关键发育时期接触的潜在生殖风险.
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