cuproptosis参与了在怀孕期间的抛物线中的小肠毒性
Juan Tang1, Zemin Xu1, Mengna Jiang1
1Department of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China.
Toxicology letters
|August 11, 2025
概括
孕期暴露于短链甲 (SCCPs) 伤害后代.
科学领域:
- 环境毒理学环境毒理学
- 发展生物学 发展生物学
- 职业健康 职业健康 职业健康
背景情况:
- 短链化 (SCCP) 是新兴的持久性有机污染物.
- 在孕期暴露后,SCCPs对后代小肠的影响尚不清楚.
- SCCP是用于各种应用的工业化学品.
研究的目的:
- 调查怀孕期间暴露于SCCP的小鼠后代的小肠损伤的可能性.
- 确定孕期SCCPs暴露对后代肠道健康的性别特异性影响.
- 探索SCCPs诱导的肠道毒性背后的分子机制.
主要方法:
- 在怀孕期间,小鼠暴露于SCCP.
- 评估后代的体重,小肠组织学,氧化应激标志物 (SOD,GSH) 和关键基因 (FDX1,DLAT,SLC31A1,LIAS) 的蛋白质/mRNA表达.
- 分析了毒性的性别特异性差异.
主要成果:
- 孕期SCCPs暴露减少了后代的体重,并在小肠中引起组织学损伤.
- 暴露于SCCPs增加了SOD活性和减少了GSH活性,表明氧化应激.
- SCCP改变了FDX1,DLAT和SLC31A1的蛋白质水平,这表明铜代谢中断.
- 女性后代比男性更容易受到SCCP诱导的小肠毒性.
结论:
- 孕期SCCPs暴露会诱导后代的性别特异小肠毒性.
- 这种毒性涉及氧化应激和铜代谢变化.
- 研究结果强调了SCCP对发育健康的潜在风险,特别是在雌性后代中.
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