加速度计测量的体力活动与脆弱水平的死亡率的剂量反应关系:一项前性队列研究

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Updated: Sep 11, 2025

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Qunyong Peng¹, Tianqi Ma², Lingfang He³

¹Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China; Center of Coronary Circulation, Xiangya Hospital, Central South University, Changsha 410008, China.

Experimental gerontology

|August 11, 2025

概括

参与中度至强度的体力活动 (MVPA) 显著降低了所有脆弱级别的死亡风险. 即使是脆弱的个体也会从MVPA中获得实质性的好处,这有助于抵消他们增加的死亡风险.

科学领域:

老年学是一门学科.
公共卫生公共卫生
运动生理学运动生理学

背景情况:

关于身体活动 (PA) 对不同脆弱程度的死亡率的长期影响的数据有限,特别是使用客观测量.
以前的研究主要依赖于自我报告的数据,这可能会限制准确性.

研究的目的:

调查不同脆弱状态的个体中设备测量身体活动和全因死亡率之间的剂量反应关系.
为了确定中度至强度的体力活动 (MVPA) 是否可以减轻与虚弱相关的死亡风险增加.

主要方法:

分析了来自英国生物库81219名参与者的加速仪数据 (平均年龄为61.88岁).
参与者根据脆弱的表型被分为强壮,脆弱前和脆弱的群体.
限制立方线和调整的危险比率 (HRs) 用于评估光强度PA (LPA),MVPA,总PA (TPA) 和全因死亡率之间的关联.

主要成果:

在LPA,MVPA,TPA和全因死亡率之间观察到显著的L形非线性关联.
较高的MVPA水平 (150-300,300-600和≥600分钟/周) 与强壮和脆弱个体的死亡风险大幅降低有关.
脆弱状态显著改变了MVPA和死亡率之间的关联 (Pinteraction = 0.007).
与MVPA水平最高的健壮个体相比,患MVPA<150分钟/周的脆弱个体的死亡风险高出约6倍.

结论:

设备测量的体力活动水平表明,在所有脆弱水平上,与死亡风险的剂量反应关系.
适度至强烈的体力活动 (MVPA) 参与提供了显著的死亡率益处,特别是在脆弱的个体.
MVPA可以部分减轻与脆弱性相关的过度死亡风险.

关键词:

加速度计的速度计.脆弱性脆弱性脆弱性死亡率死亡率死亡率身体活动身体活动

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