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杏仁体中的催产素通过依赖状态的杏仁体前额头调制来维持亲社会行为
Olivia C Meisner1,2, Olga Dal Monte1,3, Nicholas Fagan1,4
1Department of Psychology, Yale University, New Haven, Connecticut 06510.
概括
氧化注入底侧杏仁体 (BLA) 维持了灵长类的亲社会行为,但只有当社会动机很高时. 这种效应与加强神经活动和BLA与前带皮层 (ACCg) 之间的通信有关.
科学领域:
- 神经科学是一个神经科学.
- 灵长类动物学 灵长类动物学
- 社会行为 社交行为
背景情况:
- 亲社会行为对灵长类社会结构至关重要.
- 底侧杏仁体 (BLA) 和前环皮质 (ACCg) 是社会决策的关键大脑区域.
- 催产素调节社会行为和这些大脑区域,但其确切的作用尚不清楚.
研究的目的:
- 研究BLA中的催产素如何影响雄性 rhesus的亲社会行为和神经活动.
- 检查催产素对BLA和ACCG活性及其协调的依赖状态的影响.
主要方法:
- 在雄性 rhesus 的 BLA 中注入催产素或盐水.
- 评估亲社会决策,BLA和ACCG神经活动,以及区域间协调.
- 对状态依赖的行为和神经效应的分析.
主要成果:
- 氧化注入BLA在高亲社会状态下维持了亲社会选择和参与,但不是低亲社会状态.
- 在BLA和ACCG中神经活动仅在高亲社会状态下加强了亲社会选择.
- 在高亲社会状态下,催产素输注保持了BLA和ACCG之间的稳定协调.
结论:
- 催产素在维持亲社会行为的作用取决于个体的社会动机状态.
- 在BLA中的催产素作为一种状态依赖的神经调节剂,增强神经反应和沟通,对亲社会决策至关重要.
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