相关实验视频
Updated: Aug 1, 2026

10:53
Shape Memory Polymers for Active Cell Culture
Published on: July 4, 2011
13.5K
基于α-多聚胺酸的功能化聚烯基聚氨,具有集成形状记忆特性和生物活性
Jie Zhang1, Lingchen Mao1, Suyang Dai1
1State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Biomacromolecules
|August 11, 2025
概括
基于聚烯酸的新型形状记忆聚氨与α-多聚胺酸功能化,表现出优异的机械性能,形状记忆能力和用于组织工程应用的增强细胞兼容性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 组织工程是组织工程.
背景情况:
- 形状记忆聚合物 (SMP) 为组织工程提供可编程的变形.
- 开发具有结合机械强度,形状记忆和生物活性的SMP具有挑战性.
研究的目的:
- 为了合成和描述基于新型聚烯酸 (PCL) 的形状记忆聚氨,与α-多聚胺酸 (α-PLGA) 侧链 (PU-PLGA) 功能化.
- 评估用于组织工程应用的合成PU-PLGA的机械性能,形状记忆行为和体外生物性能.
主要方法:
- 基于PCL的聚氨的合成,含有不同的α-PLGA含量.
- 热分析 (结晶和融化温度).
- 机械测试 (拉力强度,破裂时的延长).
- 在实验室细胞培养研究中,使用大鼠骨髓中介质干细胞.
- 概念植入实验用于骨缺陷修复.
主要成果:
- PU-PLGA 的结晶温度为1.4-2.4°C,化温度为40-40.4°C.
- 2%的α-PLGA变体显示出高拉伸强度 (19.5 MPa) 和破裂时的延伸 (894.9%).
- 所有PU-PLGA都表现出了用于复杂形状编程的优秀形状记忆能力.
- 在体外研究证实了良好的细胞兼容性 (>80%的活力) 和显著增强的干细胞粘附,增殖和骨质分化与α-PLGA的合并.
结论:
- 新的PU-PLGA材料具有机械强度,形状记忆性能和生物活性的有希望的组合.
- 这些材料显示出作为组织工程中骨缺陷修复的支架的巨大潜力.
- α-PLGA功能化对于增强基于PCL的形状记忆聚氨的生物性能至关重要.
相关概念视频
Polymers
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Overview of Advanced Functional Groups
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
Carboxylic Acid Derivatives: Overview
Carboxylic acid derivatives are formed by replacing the hydroxyl group of carboxylic acids with a different functional group. The most common carboxylic acid derivatives are:
Polymer Classification: Stereospecificity
Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
Anionic Chain-Growth Polymerization: Overview
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
Classification and Mechanical Properties of Synthetic Polymers
Synthetic polymers are classified as elastomers, fibers, or plastics based on their crystallinity. Crystallinity, the degree of long-range order in the solid state, influences the mechanical properties (stretching or contracting) of elastomers. Elastomers are flexible polymers that can expand or contract easily upon the application of an external force. They have numerous crosslinks that pull them back into their original shape when stress is removed. Silicones, for instance, are highly elastic...

