在极度早产或出生体重极低的儿童中,8岁时的螺旋计表型
Tugba Alarcon-Martinez1, Rheanna M Mainzer2,3, Sarath Ranganathan3,4
1Newborn Services, The Royal Women's Hospital, Parkville, Victoria, Australia tugba.alarcon-martinez@thewomens.org.au.
Thorax
|August 11, 2025
概括
超过四分之一的极度早产/低出生体重的儿童有异常的螺旋计. 这些肺功能异常,包括POLD和pPRISm,因与早期生活因素的联系而有所不同.
科学领域:
- 儿科肺病学 儿科肺病学
- 新生儿医学 新生儿医学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 过早分娩与呼吸空气流量受损有关,但具体的螺旋计表现型尚未明确定义.
- 了解这些表型对于评估幸存者的长期呼吸系统健康至关重要.
研究的目的:
- 在极度早产 (EP) 或极低出生体重 (ELBW) 儿童中,在8岁时表征异常的螺旋测量表型.
- 为了确定与每个不同的螺旋计表型相关的早期 (产前和生长) 因素.
主要方法:
- 分析了EP/ELBW幸存者的8岁时的螺旋计数据和按期出生的对照.
- 确定了异常的表型:早产相关阻塞性肺病 (POLD),早产相关维护的精神测量损伤比率 (pPRISm) 和早产相关失灵症 (pDysanapsis).
- 肺体积和生命早期的变量在表型之间进行了比较.
主要成果:
- 29%的EP/ELBW儿童表现出异常的螺旋计,而对照组只有9%.
- 波兰 (8%) 和pPRISm (11%) 的表型显示空气捕获;pPRISm与肺总体体积的减少有关.
- 支气管肺功能障碍与POLD和pPRISm相关;较低的妊娠年龄和较差的早期体重增加与pPRISm相关.
结论:
- 超过25%的EP/ELBW出生的儿童存在异常的螺旋测量表型.
- 已识别的螺旋测量表型 (POLD,pPRISm,pDysanapsis) 与围产期和早期生长变量有明显的关联.
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