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长非编码RNA和自:肝细胞癌进展的双重驱动因素
Himanshi Goyal1, Jyotdeep Kaur2
1Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
长非编码RNAs (lncRNAs) 调节肝细胞癌 (HCC) 的自,影响其进展和耐药性. 准lncRNA-自轴为HCC提供了新的诊断生物标志物和治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 肝细胞癌 (HCC) 是癌症死亡的主要原因之一,结果不佳.
- 自在HCC中起着双重作用,早期抑制瘤,但后来促进存活.
- 长非编码RNAs (lncRNAs) 是细胞过程的关键调节者,包括自.
研究的目的:
- 审查自在HCC进展中的作用.
- 概述lncRNAs在HCC中的双重功能及其与自信号传递的整合.
- 探索 lncRNA-自轴作为治疗标和生物标记物.
主要方法:
- 在HCC中对自和lncRNA作用的文献综述.
- 对自信号通路的lncRNA调节的分析 (PI3K/AKT/mTOR,AMPK,贝克林-1).
- 检查HCC中 lncRNA介导的耐药性机制.
主要成果:
- 自促进了HCC的存活和晚期的进展.
- lncRNAs通过各种机制调节自,影响瘤发生和转移.
- lncRNAs通过改变自流和信号传递来影响耐药性.
- 像siRNAs和CRISPR/Cas这样针对lncRNA-自轴的新兴策略显示出临床前的希望.
结论:
- 在HCC的发展和进展中,lncRNA-自网络至关重要.
- 参与自的lncRNAs是HCC诊断,预后和复发的潜在生物标志物.
- 针对lncRNA-自轴为HCC提供了创新的治疗机会.
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