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Updated: Sep 11, 2025

Detection of Nuclear Blebbing and DNA Leakage in Mammalian Cells by Immunofluorescence
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Published on: January 17, 2025

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一个SETD2-CDK1-lamin轴保持了核形态和基因组稳定性的核形态

Abid Khan1, Cheng Zhang2, Phu G Nguyen1

  • 1Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Nature cell biology
|August 11, 2025
PubMed
概括

对于基因调节至关重要的SETD2蛋白质,也独立于其催化功能稳定了核膜. 这种非催化作用维持了基因组的完整性,并抑制了瘤的生长.

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