感染性内心炎中Clostridioides difficile感染的临床负担:单中心体验
Lorenzo Bertolino1, Augusto Delle Femine2, Anna Maria Carolina Peluso2
1Department of Precision Medicine, University of Campania 'L. Vanvitelli', Naples, Italy.
Internal and emergency medicine
|August 11, 2025
概括
艰难菌感染 (CDI) 在急性传染性内心炎 (IE) 患者中很常见,增加死亡率. 早期发现和预防CDI对于改善IE患者的存活率至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 内部医学 内部医学
- 关键护理医学 关键护理医学
背景情况:
- 艰难菌感染 (CDI) 是医院获得的腹的一个重要原因.
- 在急性传染性内心炎 (IE) 患者中,CDI的负担和影响仍未得到充分研究.
- 急性细菌性IE是一种严重的疾病,需要长时间住院和广泛的抗生素,易患CDI.
研究的目的:
- 确定患有急性细菌性IE的住院患者中CDI的发生率.
- 为了确定与该人群中CDI发展相关的临床因素.
- 评估CDI对IE患者住院死亡率的预后影响.
主要方法:
- 从2016年到2024年进行了一项单中心回顾性研究.
- 包括因急性细菌性IE住院的患者.
- 根据急性腹和阳性便测试来诊断CDI; CDI和非CDI组之间的结果进行了比较.
主要成果:
- 该研究包括370例IE病例;50 (13.4%) 患有腹,其中10 (20%) 确诊为CDI.
- CDI的发病率为每10,000名病人的病床日中17.04例.
- CDI独立地与在医院死亡率显著增加的风险相关 (HR 3.34;p=0.047).
结论:
- 在急性IE住院患者中,CDI的发病率特别高.
- 在IE患者中,CDI是降低生存率和增加住院死亡率的独立预测指标.
- 这些发现强调了急性IE管理中对CDI预防策略和及时诊断方法的关键需求.
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