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非洲毒素B1 在肝细胞癌中通过IL-6表达促进类似M2的巨分化,通过IL-6表达

Jingze Niu^1,2, Wenda Wu^1,2, Huayue Zhang^1,2

¹School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230601, China.

Digestive diseases and sciences

|August 11, 2025

概括

暴露于亚拉托克辛会通过升调IL-6促进肝癌,从而推动M2巨细胞的两极分化. 用PD1治疗向IL-6有效地减少瘤生长,并增强肝细胞癌中的抗瘤免疫力.

科学领域:

肝细胞癌研究肝细胞癌研究
免疫学免疫学免疫学
癌症治疗方法癌症治疗方法

背景情况:

中国的肝细胞癌 (HCC) 与HBV,HCV和亚拉托克辛暴露有关.
非洲毒素污染,特别是在中国南部,对健康构成重大风险,需要对其在肝癌中的作用进行研究.

研究的目的:

调查阿弗拉托辛B1 (AFB1) 在改变肝癌免疫微环境中的作用.
阐明AFB1暴露导致HCC的分子机制.
为了评估针对IL-6的治疗潜力,结合PD1治疗AFB1相关的HCC,评估IL-6的治疗潜力.

主要方法:

在体内实验验证AFB1在免疫微环境变化中的作用.
临床样本的统计和免疫组织化学分析,来自患有或没有暴露于亚拉托克辛的患者.
转录组测序以确定AFB1诱导的HCC的分子机制.
在体内动物模型中评估向IL-6和PD1治疗的协同效应.

主要成果:

AFB1通过NF-κB通路上调节IL-6的表达,促进M2类巨细胞极化.
针对IL-6和PD1的联合治疗在小鼠模型中显著抑制了瘤生长.
与PD1单独治疗相比,联合治疗减少了M2样巨细胞和增加了CD8+ T细胞透.

结论:

向IL-6是AFB1相关的肝细胞癌的一个有前途的治疗策略.
结合IL-6和PD1阻断显示出显著的抗瘤作用.
需要进一步的临床研究来将这些发现转化为改善患者的治疗结果.

关键词:

非洲毒素B1是什么?肝细胞癌是肝细胞癌.通过IL-6介导的免疫抑制.免疫治疗是一种免疫疗法.类似M2的巨细胞.

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