纳米晶体作为一种有前途的方法,用于提高使用Box-Behnken设计的埃托里可西布的溶解性和溶解性
Lamiaa M Ahmed1, Fergany A Mohamed1, Tahani H Elfaham2
1Department of pharmaceutics, Faculty of pharmacy, Assiut University, Assiut, 71526, Egypt.
Scientific reports
|August 11, 2025
概括
使用环保的酸沉方法成功制备了埃托里可西布纳米晶体. 这种方法显著提高了药物的可溶性和溶解率,为难溶性药物提供了一个有前途的策略.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 药物溶解度差是制药开发中的一个重大挑战,阻碍了生物可用性和治疗疗效.
- 纳米晶体技术提供了一种有前途的方法来提高难溶性药物的可溶性和药理动力学.
研究的目的:
- 通过将其配制成纳米晶体来改善 etoricoxib 的物理化学性质.
- 优化一个环保的酸沉方法,以制备 etoricoxib 纳米晶体.
主要方法:
- 使用酸沉方法制备了 etoricoxib 纳米晶体.
- 对稳定剂类型/度,药物量和同质化参数进行了优化.
- 描述包括FT-IR,DSC,X射线衍射和TEM;进行了溶解性和溶解性研究.
主要成果:
- 优化的埃托里科克西布纳米晶体的平均颗粒大小为210.30nm,PDI为0.277和zeta电位为-74.10mV.
- TEM成像证实了明确的立方形纳米粒子,具有形态统一性.
- 水溶性从87.70微克/毫升 (纯药物) 增加到137.75微克/毫升 (纳米晶体).
- 纳米晶体表现出快速溶解,在5分钟内实现91.49%的释放.
结论:
- 酸沉方法是有效的以提高可溶性和溶解的产生 etoricoxib 纳米晶体.
- 埃托里可西布纳米晶体代表了一种可行的策略,可以提高难溶性药物的生物可用性.
- 这种纳米晶体配方方法具有开发改进的药物输送系统的潜力.
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