男孩中部早期青春期;诊断,治疗和随访:全国性的研究
Sevinc Odabasi Gunes1, Merve Sakar2, Nursel Muratoglu Sahin2
1UHS Gulhane Training and Research Hospital, Department of Pediatric Endocrinology, Ankara, Türkiye. sevinc.odabasigunes@sbu.edu.tr.
Endocrine
|August 11, 2025
概括
评估了男孩的中心早期青春期 (CPP),发现有机CPP (oCPP) 的流行率低于之前报告的. 对于3岁以下的男孩来说,早期评估至关重要,以确定潜在的有机原因.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖健康 生殖健康
- 儿童发展 儿童发展
背景情况:
- 中部早发性青春期 (CPP) 是一种以早发性青春期为特征的疾病.
- 了解这些亚型,即异常性CPP (iCPP) 和有机性CPP (oCPP),对于有效的管理至关重要.
- 人口,临床和实验室特征影响治疗结果.
研究的目的:
- 分析患有CPP的男孩的人口,临床,实验室和成像特征.
- 评估诊断为CPP的患者的治疗反应.
- 根据MRI发现,区分异态和有机CPP.
主要方法:
- 从土耳其的儿科内分泌学诊所回顾性数据收集.
- 根据MRI,将患者分为iCPP和oCPP组.
- 将 oCPP进一步分类为确认的,无关的和不确定的子组.
主要成果:
- 232名患者中有62.9%患有ICPP; oCPP的患病率低于预期.
- 在oCPP组中观察到较高的基底LH和水平.
- 3岁以下的男孩始终呈现出 oCPP 确认的病变.
- 最终的身高受到治疗开始的身高,父亲的身高和目标身高的显著影响.
结论:
- oCPP的流行率似乎比以前记录的要低.
- 没有确定的标志物可以排除在ICPP病例中没有MRI的 oCPP.
- 在患有CPP的3岁以下男孩中,对有机原因的警评估至关重要.
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