十字花蔬菜的摄入量和结肠癌的风险:一个剂量反应元分析
Bo Lai1, Zhong Li2, Junjie Li3
1Department of Interventional Radiology, Inner Mongolia Forestry General Hospital, The Second Clinical Medical School of Inner Mongolia University for the Nationalities, No.81, Lincheng Road, 022150, Yakeshi, China.
BMC gastroenterology
|August 12, 2025
概括
更多的十字花蔬菜 (CV) 消费可能会降低结肠癌 (CC) 的风险. 这一元分析表明了剂量与反应的关系,增加的摄入量与降低的CC发病率相关.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 结肠癌 (CC) 是全球癌症死亡率的主要原因之一.
- 饮食因素,特别是十字类蔬菜 (CV),都与CC的发病有关.
- CV含有葡萄糖酸盐,产生具有化学预防性质的生物活性异硫酸酸盐.
研究的目的:
- 调查十字花蔬菜摄入量与结肠癌风险之间的定量剂量反应关系.
- 综合现有队列和病例控制研究的证据.
- 为预防结肠癌的饮食建议提供见解.
主要方法:
- 在主要数据库 (Embase,Scopus,Web of Science,PubMed,Cochrane Library) 中进行全面的文献搜索.
- 包括17项研究 (7个队列,10个病例控制) 与97595名参与者.
- 用随机效应模型和限制立方线模型进行剂量反应分析的元分析.
主要成果:
- 在心血管消耗和心血管风险 (OR=0.8;95% CI 0.72-0.90) 之间观察到显著的反向关联.
- 非线性剂量反应分析显示,随着CV摄入量增加,CC风险逐渐降低.
- 进行了出版偏见和敏感性分析,以评估研究结果的可靠性.
结论:
- 较高的十字花蔬菜摄入量可能与结肠癌的发病率降低有关.
- 这些发现表明剂量依赖的保护作用.
- 由于研究中潜在的方法限制和异质性,建议谨慎使用.
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