新诊断肺结核患者的肠道微生物群概况:印度南部的一项探索性试点研究
Tejaswini Baral1, Shaik Mohammad Abdul Fayaz2, Mohan K Manu3
1Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
Gut pathogens
|August 12, 2025
概括
肺结核 (PTB) 患者的肠道微生物多样性减少,在治疗期间情况恶化. 益生菌补充剂部分改善了多样性,但没有完全恢复肠道微生物群平衡.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 新出现的证据将肺结核 (PTB) 与肠道微生物群失生症联系起来.
- 肠道微生物群的变化可能会影响PTB病原和治疗结果.
研究的目的:
- 为了描述南印度PTB患者的肠道微生物群.
- 评估抗结核疗法 (ATT) 和益生菌补充剂对肠道微生物群多样性和组成的影响.
主要方法:
- 使用16S安普利康测序来分析肠道微生物群的组成.
- 计算了α和β多样性指标.
- 功能分析探讨了代谢途径的变化.
主要成果:
- 与健康对照组 (HC) 相比,PTB患者的肠道微生物α多样性 (Chao1指数) 显著减少.
- 在ATT期间,微生物多样性进一步下降,在β多样性分析中观察到明显的集群.
- 用ATT补充益生菌部分改善了微生物丰富性和多样性,但没有完全恢复组成.
结论:
- 在PTB患者中,即使在ATT后,持续的肠道失调也很明显.
- 针对微生物组的向疗法需要进一步研究,以管理与PTB相关的失生症.
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