在精神分裂症患者的肠道病毒组的基于元基因组的表征
Yi Ren1,2, Pan Zhang3, Hailong Yu4
1Department of Critical Care Nephrology and Blood Purification, The First Affiliated Hospital of Xi'an Jiaotong University, West Yanta Road 277, Xi'an, 710016, Shaanxi, China.
Journal of translational medicine
|August 12, 2025
概括
肠道病毒组,或肠道中的病毒群体,在精神分裂症 (SCZ) 中发生变化. 特定的病毒标志显示出作为SCZ诊断和治疗监测的非侵入性生物标志物的潜力.
科学领域:
- 微生物学 微生物学
- 精神病学是一个精神病学.
- 基因组学就是基因组学.
背景情况:
- 精神分裂症 (SCZ) 与肠道微生物失衡有关,但肠道病毒组的作用尚未得到充分研究.
- 肠道病毒基因的改变可能会导致SCZ的发病.
- 这项研究研究了SCZ患者的肠道病毒组.
研究的目的:
- 鉴定精神分裂症患者肠道病毒组合的特征.
- 确定与SCZ相关的特定病毒操作分类单位 (vOTU).
- 探索肠道病毒对SCZ的诊断潜力.
主要方法:
- 分析了来自90名SCZ患者和81名对照组的便元基因组数据.
- 确定了肠道病毒组多样性和SCZ相关的vOTU.
- 使用随机森林模型评估病毒-细菌相关性和诊断潜力.
主要成果:
- 在SCZ患者和对照人群之间,有171个VOTU显著不同,其中124个富含SCZ.
- 在SCZ中观察到改变的病毒-细菌相互作用,与特定的细菌种群相关.
- 基于病毒组的分类器在SCZ诊断中实现了93.2%的AUC,优于细菌模型.
结论:
- 在SCZ中存在明显的肠道病毒组变化.
- 特定的病毒标志物显示出SCZ的强烈诊断潜力.
- 肠道病毒组是SCZ诊断和治疗开发的有希望的非侵入性生物标志物.
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