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Updated: Sep 11, 2025

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中性细胞外细胞陷通过扰乱调节性T细胞分化来加剧牙周炎

Beibei Chen1, Danni Song1, Tianfan Cheng2

  • 1Shanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Orthodontics, Stomatological Hospital and Dental School, Tongji University, Shanghai, China.

Genes and immunity
|August 12, 2025
PubMed
概括

过度的中性粒细胞外细胞陷 (NETs) 通过阻碍调节性T细胞 (Treg) 分化,加剧牙周炎骨质损失. DNase I治疗恢复了Treg功能,这表明了治疗牙周炎的新型免疫疗法.

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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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