亚托皮肤炎和自身免疫结缔组织疾病:系统性审查和元分析
Somaia Naassan1, Misbah Noshela Ghazanfar1, Simon Francis Thomsen1,2
1Department of Dermato-Venereology & Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark.
Dermatology practical & conceptual
|August 12, 2025
概括
亚托邦性皮肤炎 (AD) 与自身免疫性结缔组织疾病 (ACTD) 的更高风险有关. 这包括类风湿性关节炎,狼,Sjögren综合征,以及多质神经炎/皮质神经炎.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 皮肤病学 皮肤病学
背景情况:
- 亚型皮肤炎 (AD) 和自身免疫性结缔组织疾病 (ACTD) 之间的关系仍未得到充分研究.
- 了解这种关联对于全面的患者护理和疾病管理至关重要.
研究的目的:
- 系统地审查和分析有关AD和ACTD之间关联的现有文献.
- 量化患有AD的人患有ACTD的风险.
主要方法:
- 在主要数据库 (PubMed,Embase,Cochrane Library,Web of Science) 中进行了系统的文献搜索.
- 包括报告AD患者中ACTD流行,发病率或风险的研究.
- 聚合赔率比率 (OR) 和95%置信区间 (CI) 使用随机效应建模计算.
主要成果:
- 分析包括18项研究,显示AD和ACTD之间具有统计学意义的总体关联 (OR 1.76).
- 对于类风湿性关节炎 (RA) (OR 1.40),全身性红斑狼 (SLE) (OR 1.92),Sjögren综合征 (SS) (OR 2.08),以及多质肌炎/皮质肌炎 (PM/DM) (OR 2.37) 发现了显著的关联.
- 对于结性脊髓炎 (AS) 或全身性硬皮病 (SSc) 没有观察到显著的关联.
结论:
- 亚托匹性皮肤炎与患上某些自身免疫结缔组织疾病的风险增加有关.
- 这些发现突出了特定的ACTD,包括RA,SLE,SS和PM / DM,这些在AD患者中更频繁地观察到.
- 进一步的研究可能会阐明阿尔茨海默病和这些自身免疫性疾病之间的共同病因路径.
相关概念视频
Connective Tissue Cell Types
3.4K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.4K
Autoimmune Disorders
672
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
672
Introduction to Connective Tissues
10.5K
Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
10.5K
Genome-wide Association Studies-GWAS
14.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.2K
Skin Diseases and Disorders
4.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.1K
T Cell Types and Functions
1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.4K


