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Updated: Jul 6, 2026

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host
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In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

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通过Leishmania调节纤维细胞行为:了解皮肤Leishmaniasis疾病进展的途径

Tarcisio Navegante de Queiroz Filho1, Brenda Furtado Costa2,3, Ana Paula Drummond Rodrigues4,5

  • 1Department of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.

BMC microbiology
|August 12, 2025
PubMed
概括

莱什曼尼亚寄生虫调节纤维细胞的行为,影响组织修复. 莱什马尼亚亚马逊种有助于愈合,而莱什马尼亚巴西种则促进皮肤莱什马尼亚病的炎症和损伤.

关键词:
莱什曼亚亚马逊人种 (Leishmania amazonensis) 是一个亚马逊人种.葡萄牙白 (Leishmania braziliensis) 是一种葡萄牙白.有条件的介质.纤维母细胞细胞是如何形成的巨细胞是一个巨细胞.金属蛋白酶是指一种金属蛋白质.

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Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...