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在感染了Blastocystis物种的慢性白血病患者中评估免疫和血液学参数

Heba Elhadad¹, Bassam Mohamed Abdel-Fattah², Sally A M Saleh³

¹Department of Parasitology, Medical Research Institute, Alexandria University, Alexandria, Egypt.

|August 12, 2025

概括

胚胎囊 spp. 的种类. 感染在慢性白血病患者中很常见 (60%的患病率). 这种寄生虫感染与较高的IL-8水平和白细胞数量有关,但不是特定的抗体或胃肠道症状.

科学领域:

医学寄生虫学医学寄生虫学
免疫学免疫学免疫学
血液学血液学血液学

背景情况:

胚胎囊 spp. 的种类. 是一种常见的肠道原生动物,具有有争议的致病性,通常与胃肠道问题有关,并且在免疫受损的个体中普遍存在.
慢性白血病患者代表了一个因其免疫状况受损而易受机会性感染的脆弱人群.

研究的目的:

为了确定布拉斯托西斯菌种的流行率. 慢性白血病患者的感染.
为了调查Blastocystis spp.之间的关联. 感染和特定的免疫学 (抗芽细胞IgA/IgG,CD4 T细胞) 和血液学 (IL-8,白细胞计数) 参数.

主要方法:

从100名慢性白血病患者收集了便和血液样本.
检测到的胚胎囊 spp. 使用显微镜和coproantigen测定.
评估了抗芽细胞体IgA/IgG抗体,CD4 T细胞计数和血清IL-8水平.

主要成果:

胚胎囊 spp. 的种类. 在研究队列中,感染流行率为60%.
感染与升高的IN-8 (IL-8) 水平和增加的白细胞 (WBC) 计数显著相关.
在Blastocystis spp.之间没有发现显著的关联. 感染和抗母细胞囊抗体水平,CD4 T细胞计数或胃肠道症状.

结论:

慢性白血病患者表现出高患病率的细胞囊 spp. 感染. 感染.
升高的IL-8水平与胚胎囊种类明显相关. 在这个患者群体中感染.

关键词:

胚胎囊发生.在CD4,IL8和CD4之间.慢性淋巴细胞白血病慢性淋巴细胞白血病这是一种coproantigen.艾丽莎·伊丽莎·伊丽莎豁免权是一种豁免权.

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