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玉米衍生LQQQLL通过mTOR信号通路和肠道微生物群减轻骨肌肉衰减

Danjun Guo¹, Hang Zou¹, Mingyue Chen¹

¹School of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China; Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan 430023, China.

Food research international (Ottawa, Ont.)

|August 12, 2025

概括

玉米 (CPs) 和一种特定的,LQQQLL,通过激活PI3K/AKT/mTOR通路并改善肠道微生物群平衡,显示出减轻骨肌肉缩的潜力.

科学领域:

生物化学和分子生物学
老年学和老年病学在老年学和老年病学.
营养科学营养科学

背景情况:

骨肌缩,特别是缩症,是与衰老和疾病相关的重大健康问题.
识别用于打击肌肉损失的新型治疗剂对于改善受影响人群的生活质量至关重要.

研究的目的:

准备和识别来自玉米的新,具有减轻骨肌肉缩的潜力.
阐明这些的抗缩作用背后的分子机制.

主要方法:

两步酶化水解和分子对接用于的制备和选.
用衰老的C2C12细胞进行了体外测试,并使用肉症小鼠模型进行了体内研究.
分析包括DPPH自由基清除,细胞增殖,生物化学标记,肌肉组织学,蛋白质表达和肠道微生物群概况.

主要成果:

玉米 (CPs) 显示出抗氧化活性,识别的片段,包括LQQQLL,与mTORC1和FOXO有很高的亲和力.
LQQQLL显著增强了衰老肌肉细胞的增殖.
在麻症小鼠中,CP和LQQQLL改善了肌肉质量,抗氧化能力和肌肉纤维特征,同时调节了肠道微生物群组成.

结论:

玉米,特别是LQQQLL,在减轻骨肌肉缩方面表现出显著的潜力.
该机制涉及PI3K/AKT/mTOR信号通路的激活和肠道微生物组的有益调节.
这些发现表明CP和LQQQLL是治疗萨科佩尼亚的有希望的天然化合物.

关键词:

玉米 (CPs) 是一种玉米.我们的肠道微生物群.LQQQLLLLLLLLLLLL 是一个很棒的游戏.萨尔科佩尼亚是什么意思萨尔科佩尼亚在mTOR信号通道上.

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