对主观认知衰退进展的预测模型的开发:一项纵向研究
Wenyi Li1,2, Jiwei Jiang2,3, Qiwei Ren1,2
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Brain and behavior
|August 12, 2025
概括
在主观认知衰退中预测阿尔茨海默病的进展是可能的. 睡眠质量差和左前脑血流减少是早期检测的关键指标.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 主观认知衰退 (SCD) 代表了阿尔茨海默病 (AD) 的临床前阶段.
- 影响SCD进展的因素尚未完全理解.
- 需要用于SCD认知进展的预测模型.
研究的目的:
- 为了确定SCD进展的风险因素.
- 开发SCD患者认知衰退的预测模型.
- 评估预测模型的临床实用性.
主要方法:
- 纳入了96名患有SCD的参与者和36名健康对照 (HCs).
- 在大约12个月内收集了临床,认知和神经成像数据.
- 考克斯的比例危险回归模型被用来构建一个名ogram.
主要成果:
- 与HC相比,SCD参与者表现出更差的睡眠质量 (更高的PSQI得分) 和在特定的大脑区域增加的大脑血流 (CBF).
- 较差的睡眠质量和左下先性CBF独立地与SCD进展有关.
- 开发的诺米图表显示出良好的区分能力 (AUC=0.785) 和临床益处.
结论:
- 一个结合匹兹堡睡眠质量指数 (PSQI) 评分和左前肌CBF的预测模型准确地预测了SCD的进展.
- 这个模型为早期阿尔茨海默病查提供了宝贵的见解.
- 这些发现强调了睡眠质量和特定的神经成像标志物在阿尔茨海默病进展中的重要性.
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