FGID与焦虑之间的双向关系:病理生理机制和新的治疗策略
1Gastroenterology Department, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, 150001 Harbin, Heilongjiang, China.
Actas espanolas de psiquiatria
|August 12, 2025
概括
功能性胃肠道疾病 (FGID) 和焦虑障碍有着双向的关系,通常涉及脑肠轴功能障碍. 综合治疗将药物,治疗和生活方式的改变相结合,改善了患者的治疗结果.
科学领域:
- 神经胃肠病学和精神病学
- 肠-大脑轴研究研究
- 伴发病性研究研究.
背景情况:
- 功能性胃肠道疾病 (FGID) 和焦虑障碍经常同时发生.
- 复杂的双向关系和潜在的机制仍然不太清楚.
- 在FGID患者中高患焦虑率,反之亦然,突出了重要的联系.
研究的目的:
- 探索FGID和焦虑障碍之间的双向关系.
- 为了阐明潜在的病理生理机制.
- 为伴随性疾病提出新的诊断和治疗策略.
主要方法:
- 对最近的研究进行了全面的文献综述.
- 对影响FGID和焦虑的相互因素的分析.
- 识别共享的神经生物学,内分泌和免疫路径.
主要成果:
- 焦虑障碍在FGID患者中更为普遍,而FGID症状在焦虑患者中更为普遍.
- 脑肠轴功能障碍,涉及神经,内分泌和免疫系统,是核心机制.
- 肠道失生症,遗传学和早期生活压力也可能有很大的贡献.
结论:
- 结合药理学 (例如,SSRI,SNRIs),心理 (例如,CBT,MBSR) 和微生物群调节 (例如,益生菌,低FODMAP饮食) 的综合治疗模式最有效.
- 建议采用个性化治疗计划的多学科方法.
- 综合诊断,包括对FGID患者的焦虑查,反之亦然,可以改善结果.
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