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一个基于血液触发和自穿透粘附的单组件粘合海绵,用于强大的血管闭塞

Rong Wang^1,2, Weishi Zheng^1,2, Yuxuan Huang^1,2

¹Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, 310058, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|August 12, 2025

概括

一种新型的体液触发粘合海绵MonoSeal利用自行透粘合 (APA) 来自发地穿透和密封组织. 这种医疗粘合剂在没有外部刺激的情况下实现了强大的湿粘和伤口密封,为具有挑战性的手术条件提供了有前途的解决方案.

科学领域:

生物材料科学生物材料科学
外科手术粘合剂的使用方法
组织工程是组织工程.

背景情况:

在潮湿,出血的条件下实现有效的医疗粘附是一种重大的临床挑战.
目前的聚合物基粘合剂通常需要外部刺激来激活,这限制了它们的实际应用.
开发可自激活的粘合剂,确保坚固的组织整合,对于推进外科手术程序至关重要.

研究的目的:

为了介绍MonoSeal,一个新的体液触发的粘合海绵.
阐明自行透粘附 (APA) 的机制,用于自发的组织透和共价结合.
评估MonoSeal在实现湿粘和伤口密封方面的有效性,包括其作为血管关闭装置的潜力.

主要方法:

单一氧化多糖体海绵MonoSeal被开发用于通过自行透粘附 (APA) 进行操作.
APA机制涉及度梯度驱动的扩散,用于自发的聚合物链透到潮湿的组织.
粘合剂的性能由其与组织氨基酸形成共价键的能力和通过蛋白质交叉链接创建局部屏障来评估. 在猪的股骨动脉和动脉上测试了有效性.

主要成果:

MonoSeal在30秒内证明了强大的组织粘附和有效密封猪大腿动脉中的12 Fr穿刺伤口.
自行透粘附 (APA) 机制使自发透和共价结合能够在没有外部激活的情况下实现.
当与定制的应用器一起使用时,MonoSeal显示出作为在猪动脉中进行干预手术的血管关闭装置的前景.

结论:

MonoSeal代表了医疗粘合剂的重大进步,提供了强大的湿和伤口密封能力.
新的自动穿透粘附 (APA) 机制提供了一种自我驱动的组织整合方法,克服了现有技术的局限性.
MonoSeal显示出临床应用的巨大潜力,特别是在血管关闭和手术期间管理出血方面.

关键词:

身体液体触发触发器链条透链条透链条透强的粘合海绵是一种强的粘合海绵.血管闭塞装置是一种血管闭塞装置.

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