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Yajun Xu^1,2, Jincheng Du^1,2,3, Ya Liu^1,2,4

¹State Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, China.

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

|August 12, 2025

概括

携带前药物的纳米颗粒通过向瘤内的Toll-like受体7/8 (TLR7/8) 和干扰素基因刺激器 (STING) 激动剂来精确地激活癌症免疫力,提高疗效和减少副作用.

科学领域:

瘤疾病纳米医学纳米医学
癌症免疫疗法癌症免疫疗法
药物输送系统药物输送系统

背景情况:

癌症免疫疗法面临着系统性药物毒性和非目标效应的挑战.
预制药载入的纳米粒子提供有针对性的输送,以增强瘤药物丰富性和选择性.
像托尔类受体7/8 (TLR7/8) 和干扰素基因刺激剂 (STING) 激动剂这样的辅助剂显示出有希望的结果,但需要瘤特定的激活.

研究的目的:

审查前期药物载入纳米颗粒的进展,以便在瘤中提供精确的辅助剂.
专注于利用托尔类受体7/8 (TLR7/8) 和干扰素基因刺激剂 (STING) 激素的纳米粒子.
讨论临床翻译挑战和这些纳米药物的未来方向.

主要方法:

对癌症免疫疗法辅助剂的前药载入纳米颗粒的最新文献进行系统分析.
讨论瘤微环境驱动的和外部触发的前药激活机制.
探索这些纳米粒子的通用设计原则.

主要成果:

含有前期药物的纳米颗粒可以控制辅助剂的释放,提高瘤选择性.
有针对性的输送策略增强了瘤中TLR7/8和STING激动剂的丰富.
这些方法旨在提高抗瘤免疫力,同时尽量减少全身毒性.

结论:

含有原药的纳米粒子是针对癌症免疫治疗的有前途的策略.
需要进一步开发,以克服TLR7/8和STING激动剂的临床翻译方面的挑战.
优化纳米药物设计可以提高治疗效果和癌症治疗中的患者安全.

关键词:

刺痛的激动剂是刺痛的激动剂 TLR7/8激素激进剂的使用情况辅助剂辅助剂是一种辅助剂.免疫疗法免疫疗法纳米颗粒是一种纳米粒子.

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