慢性精神分裂症患者的肥胖,细胞因子和精神病理学
Menghan Lv1, Xuan Wang1, Xiayue He1
1Peking University HuiLongGuan, Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China.
Frontiers in psychiatry
|August 12, 2025
概括
在精神分裂症患者中,较高的体重指数 (BMI) 与较低的IL-2和改变的精神病理相关. 瘤亡因子-α (TNF-α) 可能影响症状严重程度,表明复杂的代谢和免疫相互作用.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 在接受抗精神病治疗的精神分裂症患者中,肥胖和异常的细胞因子水平很常见.
- 细胞因子,肥胖和精神分裂症精神病理学之间的联系需要进一步调查.
研究的目的:
- 探索身体质量指数 (BMI),血清细胞因子水平和慢性精神分裂症患者的临床症状之间的关联.
主要方法:
- 一项对201名慢性精神分裂症患者的横截面研究,分为高BMI (≥25kg/m2) 和低BMI (<25kg/m2) 组.
- 使用正负综合征量表 (PANSS) 评估的精神病理学.
- 在69名参与者中测量了血清细胞因子 (IL-2,IL-6,TNF-α) 和代谢参数.
主要成果:
- 在BMI和IL-2之间发现了负相关性 (p=0.013).
- 瘤亡因子-α (TNF-α) 与PANSS总和一般精神病理学分数 (p=0.010,p=0.042) 呈反向相关性.
- 与低BMI组相比,高BMI组显示较低的PANSS负子值和高葡萄糖,甘油三和阿波利波蛋白B (ApoB) (所有p<0.05).
结论:
- 精神分裂症的BMI增加与IL-2减少,较轻的负面症状和不利的脂质状况有关.
- TNF-α可能在调节精神病理严重程度方面发挥作用.
- 研究结果表明,代谢问题,免疫标记物和精神分裂症的临床症状之间存在复杂的相互作用.
相关概念视频
Psychological and Sociocultural Causes of Schizophrenia
187
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
187
Obesity
614
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
614
Biological Causes of Schizophrenia
149
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
149
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
957
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
957
Psychoneuroimmunology: Diabetes and Cancer
62
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
62
Psychoneuroimmunology: Cardiovascular Disease
78
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
78


